TOKYO UNIVERSITY OF AGRICULTURE ANDTECHNOLOGY Biotechology and Life Science

Faculty

Cell engineering

  • Mikako Saito
    Mikako Saito

Disease model cells of diabetes.Regenerative cell engineering. ES cells.Single-cell gene engineering. Femtoinjection.Food safety control and regulatory science.
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  • Tetsushi Mori

In our lab, we drive towards the exploitation and elucidation of the characteristics, role and molecular traits of novel/uncultivable environmental microorganisms using molecular biology based approaches.
Website

Biomolecular and structural informatics

  • Yutaka Kuroda
    Yutaka Kuroda

Structural and functional analysis of proteins at atomic/molecular level using recombinant DNA technologies, NMR, X-ray crystallography, and computational simulation. Biophysical studies of protein aggregation.
Website

Structure and cellular function of biomolecules

  • Yasumoto Nakazawa
    Yasumoto Nakazawa

i) Structural analysis of silk fibroins.
ii) Development of the medical implantation devices such as artificial cardiac valves and cardiovascular patches based on the silk fibroin.
Website

Molecular biology and pathophysiology

  • Masaki Inada
    Masaki Inada
  • Michiko Hirata
    Michiko Hirata

Molecular pathological investigation using gene targeted mice and disease models on mice.
lnvestigations of refractory diseases for clinical drug development are employed for lifestyle-related diseases such as Cancer,Osteoporosis, Rheumatoid Arthritis and Periodonititis. Functional analysis of molecular biochemistry using mammalian cell to individuals are promoted research.
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  • Yoshihiro Ohta

Development of novel techniques for organelle imaging and their application to mitochondrial study. Cell death, Ca2+ signaling and generation of reactive oxygen species are mainly focused.
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Plant biotechnology

  • Yoshihiro Ozeki
    Yoshihiro Ozeki
  • Akiyo Yamada
    Akiyo Yamada

Molecular biological and biochemical studies on the enzymes involved in plant secondary metabolisms. Molecular biological analysis of the genes based on the functin of the proteins related to salt-tolerance phenotype of the halophyte.
Website

Biobusiness and Molecular Biochemistry

  • Wakako Tsugawa
    Wakako Tsugawa

Biomolecular engineering for the development of 1) novel enzymes for the diagnostic application,and 2) novel proteins for the application in the synthetic biology. Development of novel biodevices for the creation of theranostic platforms and environmental monitoring systems.
Website

  • Ryutaro Asano
    Ryutaro Asano

Artificial protein design based mainly on antibody molecules and their detailed functional analyses for development of next-generation biologicals and biosensors.
Website

Nanobiotechnology

  • Kazunori Ikebukuro
    Kazunori Ikebukuro

  • Kaori Tsukakoshi

I focus on the interaction between nucleic acids and proteins and apply it to develop biosensing system for new biomarkers or epigenetic modification. I am also engaged in the evolutionary molecular engineering research to improve function of nucleic acids and proteins to adjust those to those applications using computer.
Website

  • Ryuji Kawano
    Ryuji Kawano

The goal of my research is to establish a system that uses biological nanopores for single-molecule detection. Channel membrane proteins have nanochannels around 1 nm in size. These biological nanopores are capable of detecting and electrically recognize even single molecules with a high signal-to-noise ratio. However, the channel size is limited by the inherent protein structure. I plan to develop artificial nanochannels such as synthetic nanopores or polypeptides combined with biomaterials (proteins and lipid bilayers) on the basis of MEMS technology for novel nanopore sensing.
Website

Biomolecular Engineering and Marine Biotechnology

  • Tsuyoshi Tanaka
    Tsuyoshi Tanaka
  • Atsushi Arakaki
    Atsushi Arakaki
  • Tomoko Yoshino
    Tomoko Yoshino

  • Yoshiaki Maeda

Production of biofuels, chemicals and pharmaceuticals on the basis of biological functions of various microorganisms. /Development of Bio-sensing system based on lab-on-a-chip technologies.
Molecular analysis of biomineralization mechanism. Biomimetic synthesis of organic/inorganic hybrid nanomaterials using biological molecules.
Development of novel bio-nanomaterials through genetic engineering by microorganisms for biosensing and biomedical applications.
Website

Bioelectronics and Marine Biotechnology

  • Nobuhumi Nakamura
    Nobuhumi Nakamura
  • Masaki Tanaka
    Masaki Tanaka

Bioelectrochemistry and Raman spectroscopy of metalloproteins and construction of biofuel cells.
Website

  • Takahiro Ichikawa
    Takahiro Ichikawa

Self-organization of liquid crystals provides well-ordered and highly-defined nanostructures, and therefore they have attracted increasing attention in the field of the development of next-generation soft materials. Among various liquid-crystalline materials, we have focused on bicontinuous cubic liquid crystals with expecting their three-dimensionally continuous nanostructures. Bicontinuous cubic structures are composed of three-dimensionally interwoven nanochannel domains and a surrounding sheath domain. Owing to their continuous structures, their application for nanostructured materials are now strongly expected.
Website

Synthetic organic chemistry, Bioorganic chemistry/chemical biology


  • Kazuo Nagasawa

  • Minami Odagi

Total synthesis of biologically active natural products. Development of organocatalyst.
Website

  • Masayuki Tera
    Kaori Sakurai

Design and synthesis of functional small molecules controlling live cells and nucleic acids–protein interactions based on bioorthogonal reactions. Biological evaluation of the synthesized small molecules to apply to regenerative medicine and drug discovery.
Website

  • Kaori Sakura
    Kaori Sakurai

Development of novel chemical tools to study biological functions of glycolipids and natural products.
Website

Biosociety engineering, Biomolecules and proteomics

  • Masafumi Yohda
    Masafumi Yohda
  • Keiichi Noguchi
    Keiichi Noguchi

  • Yosuke Fukutani

Structure and function of molecular chaperones. Genetic analysis systems for SNP genotyping and bioremediation. Structure and function of metalloenzymes. Protein X-ray crystallography.
Website

  • Kyosuke Shinohara
    Kyosuke Shinohara

We examine role of cilia in our body. Cilia are nanomachine motor devices that protrude from cell surface and play important role on transport of fluid in airway, brain, and oviduct. Using knockout mouse, electron microscopy, and protein engineering, we address molecular basis of motility and mechanical property of cilia: How cilia move or how cilia acquire their stiffness and integrity.

Systembiology


  • Hiroshi Tsugawa

Our laboratory performs the research of systems biology through the development of mass spectrometry omics techniques that illuminate the diversity of metabolites from plant, human, and the associated microbiome.
Website

Medicinal enzyme engineering


  • Christopher John Vavricka Jr.

Computationally-driven enzyme engineering enables the sustainable biosynthesis of virtually any desired chemical product. Therefore, we are developing computational approaches for the discovery and engineering of specialized enzymes that can extend metabolic pathways to produce valuable medicinal compounds.
Website

Theoretical linguistics

  • Yuji Hatakeyama
    Yuji Hatakeyama

I study theoretical linguistics.
Website

Environmental Genome Technology (Collaborative Study Field)

  • Chikashi Nakamura
    Chikashi Nakamura
  • Hyonchol Kim
    Hyonchol Kim

Cell engineering based on nanotechnology aiming to use iPS cells or somatic stem cells practically for the regenerative medicine. Genome engineering based on high-throughput genome analysis aiming to make fine products from the gene resources of Aspergillus oryzae used for Japanese traditional fermentation industries or the related species. Website

Collaborative Organization
National Center of Neurology and Psychiatry (NCNP)