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Publications (Kazuo Nagasawa)

[219]Topology-Selective Photo-Crosslinking of G-Quadruplexes via Dual G-Quartet and Groove Recognition

Ryo Ishikawa, Kazuki Yanagida, Sayuri Shimada, Shogo Sasaki, Takatsugu Hirokawa, Yue Ma, Kazuo Nagasawa and Masayuki Tera
Chem. Commun. 2024, DOI:10.1039/D4CC04804K

[218] Discovery and Structural Analysis of Metabolites of Vitamin D3 Lactones

Kazuto Iijima , Ryota Sakamoto , Rino Tsutsumi , Naoto Nakaya , Takatsugu Hirokawa , Minami Odagi , Toshiyuki Sakaki , Kaori Yasuda , Kazuo Nagasawa
Chem. Pharm. Bull. 2024, Volume 72 Issue 10 Pages 899-908　 DOI:10.1248/cpb.c24-00495

[217] Synthesis of Saxitoxin Biosynthetic Intermediates: Reveal the Mechanism for Formation of its Tricyclic Skeleton in Biosynthesis

Ryosuke Hirozumi, Mayu Hakamada, Takashi Minowa, Yuko Cho, Yuta Kudo, Keiichi Konoki, Yasukatsu Oshima, Kazuo Nagasawa, Mari Yotsu-Yamashita
Chem. Asian J. 2024, Article number:e202400834. DOI:10.1002/asia.202400834

[216] Synthesis and Identification of decarbamoyloxySaxitoxins in Toxic Microalgae and their Reactions with the Oxygenase, SxtT, Reveal Saxitoxin Biosynthesis

Mayu Hakamada, Chihiro Tokairin, Hayate Ishizuka, Kanna Adachi, Toma Osawa, Shiori Aonuma, Ryosuke Hirozumi, Shigeki Tsuchiya, Yuko Cho, Yuta Kudo, Keiichi Konoki, Yasukatsu Oshima, Kazuo Nagasawa, Mari Yotsu-Yamashita
Chem. Eur. J. 2024, 30, accepted.

[215] Differential gene regulation by a synthetic vitamin D receptor ligand and active vitamin D in human cells

Miho Iwaki, Yoshiaki Kanemoto, Takahiro Sawada, Koki Nojiri, Tomohiro Kurokawa, Rino Tsutsumi, Kazuo Nagasawa, Shigeaki Kato
PLOS ONE 2023, 18, Article number:e0295288 . DOI: 10.1371/journal.pone.0295288

[214] Differential Metabolic Stability of 4α,25- and 4β,25-Dihydroxyvitamin D3 and Identification of Their Metabolites

Yuka Mizumoto, Ryota Sakamoto, Kazuto Iijima, Naoto Nakaya, Minami Odagi, Masayuki Tera, Takatsugu Hirokawa, Toshiyuki Sakaki, Kaori Yasuda, Kazuo Nagasawa
Biomolecules 2023, 13, Article number:1036. DOI: 10.3390/biom13071036

[213] Regulation of Thrombin Activity by Ligand-Induced Topological Alteration in Thrombin-Binding Aptamer

Shogo Sasaki, Yue Ma, Takatsugu Hirokawa, Kazunori Ikebukuro, Masayuki Tera, Kazuo Nagasawa
Chem. Commun. 2023 , 59 , 8862-8865. DOI: 10.1039/D3CC02308G

[212] Approaches to Construction of the Medium-Sized Ring Structure in Zetekitoxin AB by Ring-Closing Metathesis

Hayate Ishizuka, Ayato Nureki, Kanna Adachi, Yuka Takayanagi, Minami Odagi, Mari Yotsu-Yamashita, Kazuo Nagasawa
J. Org. Chem. 2023 , 88 , 10223-10231. DOI: 10.1021/acs.joc.3c00580

[211] Stereoselective Construction of Tertiary Alcohol at C11 of Zetekitoxin AB

Ayato Nureki, Kanna Adachi, Hayate Ishizuka, Kako Maeno, Yayoi Orihara, Minami Odagi, Mari Yotsu-Yamashita, Kazuo Nagasawa
Asian J. Org. Chem. 2023 , 12 , e202300205. DOI: 10.1002/ajoc.202300205

[210] Synthesis of Pentacyclic Core Structure of Aspidosperma Alkaloids by Sequential Ring Construction Via Oxidative Phenolic Coupling

Minami Odagi, Keisuke Hosoya, Kazuo Nagasawa
Chem. Lett. 2023 , 52 , 381-384. DOI: 10.1246/cl.230106

[209] A 1,3-Boron Shift Reaction of Homoallenylboronates to Synthesis of 2-Boryl-1,3-Dienes

Ryota Sakamoto, Minami Odagi, Masahiro Yamanaka, Kazuo Nagasawa
Chem. Commun. 2023, 59, 4217-4220. DOI: 10.1039/D2CC06600A

[208] Enantioselective Oxidative Enolate Coupling of Oxindoles Catalyzed by Chiral Guanidinium Hypoiodite

Minami Odagi, Io Mori, Kota Sugimoto, Kazuo Nagasawa
ACS Catal. 2023, 13, 2295-2301. DOI: 10.1021/acscatal.2c05677

[207] Guanidinium Hypoiodite-Catalyzed Intramolecular Oxidative Coupling Reaction of Oxindoles with β-Dicarbonyls

Kota Sugimoto, Io Mori, Takanari Kato, Koji Yasui, Ban Xu, Choon Hong Tan, Minami Odagi, Kazuo Nagasawa
J. Org. Chem. 2023, 88, 7660-7673 . DOI: 10.1021/acs.joc.2c02500

[206] Nontoxic Enantiomeric Reference Materials for Saxitoxins

Ryuichi Watanabe, Yuka Takayanagi, Osamu Chiba, Shota Itoda, Hayate Ishizuka, Minami Odagi, Mayu Ozawa, Hajime Uchida, Ryoji Matsushima, Keiichi Konoki, Mari Yotsu-Yamashita, Kazuo Nagasawa, Toshiyuki Suzuki
Anal. Chem. 2022, 94, 11144-11150. DOI: 10.1021/acs.analchem.2c00836

[205] Effects of G-quadruplex ligands on the topology, stability, and immunostimulatory properties of G-quadruplex-based CpG oligodeoxynucleotides

Anh Thi Tram Tu, Kazuaki Hoshi, Yue Ma, Taiji Oyama, Satoko Suzuki, Kaori Tsukakoshi, Kazuo Nagasawa, Kazunori Ikebukuro, Tomohiko Yamazaki
ACS Chem. Biol. 2022, 17, 1703-1713. DOI: 10.1021/acschembio.1c00904

[204] Stereodivergent Synthesis of 1,3-Dienes via Protodeboronation of Homoallenylboronic Esters

Ryota Sakamoto, Minami Odagi, Atsuto Izumiseki, Kaname Konuki, Kazuo Nagasawa
J. Org. Chem. 2022, 87, 8084-8098. DOI: 10.1021/acs.joc.2c00744

[203] Single-molecule displacement assay reveals strong binding of polyvalent dendrimer ligands to telomeric G-quadruplex

Pravin Pokhrel, Shogo Sasaki, Changpeng Hu, Deepak Karna, Shankar Pandey, Yue Ma, Kazuo Nagasawa, Hanbin Mao
Anal. Biochem. 2022, 649, Article number: 114693. DOI: 10.1016/j.ab.2022.114693

[202] Synthesis of deuterium-labeled vitamin D metabolites as internal standards for LC-MS analysis

Akiko Nagata, Kazuto Ijima, Ryota Sakamoto,Yuka Mizumoto, Miho Iwaki, Masaki Takiwaki, Yoshikuni Kikutani, Seketsu Fukuzawa, Minami Odagi, Masayuki Tera, Kazuo Nagasawa
Molecules 2022, 24, Article number:2427. DOI: 10.3390/molecules27082427

[200] Synthesis of C2-Alkoxy-Substituted 19-Nor Vitamin D3 Derivatives: Stereoselectivity and Biological Activity

Yuka Mizumoto, Ryota Sakamoto, Akiko Nagata, Suzuka Sakane, Atsushi Kittaka, Minami Odagi, Masayuki Tera, Kazuo Nagasawa
Biomolecules 2022, 12, Article number:69. DOI: 10.3390/biom12010069

[199] Enantioselective Total Synthesis of Cepharatines via Bioinspired Ring Reconstruction

Minami Odagi, Taisei Matoba, Kazuo Nagasawa
J. Org. Chem. 2022, 87, 1065-1073. DOI: 10.1021/acs.joc.1c02371

[198] Controlled lipid β-oxidation and carnitine biosynthesis by a vitamin D metabolite

Aileen Mendoza, Yasushi Takemoto, Kevin Tan Cruzado, Shadi Sedghi Masoud, Akiko Nagata, Ajcharapan Tantipanjaporn, Satoshi Okuda, Fumihiro Kawagoe, Ryota Sakamoto, Minami Odagi, Sayuri Mototani, Moeka Togashi, Makoto Kawatani, Harumi Aono, Hiroyuki Osada, Hayato Nakagawa, Tatsuya Higashi, Atsushi Kittaka, Kazuo Nagasawa, Motonari Uesugi
Cell Chem. Biol. 2022, 29, 660-669. DOI: 10.1016/j.chembiol.2021.08.008
農工大プレスリリース

[197] Detection of CpG methylation in G-quadruplex Forming Sequences using G-quadruplex ligands

Hijiri Hasegawa, Ikkei Sasaki, Kaori Tsukakoshi, Yue Ma, Kazuo Nagasawa, Shusuke Numata, Yuuki Inoue, Yeji Kim, Kazunori Ikebukuro
Int. J. Mol. Sci. 2021, 22, Article number:13159. DOI: 10.3390/ijms222313159

[196] Vinylnaphthalene-bearing hexaoxazole as a fluorescence turn-on type G-quadruplex ligand

Yue Ma, Yuki Wakabayashi, Naruyuki Watatani, Ryota Saito, Takatsugu Hirokawa, Masayuki Tera, Kazuo Nagasawa
Org. Biomol. Chem. 2021, 19, 8035-8040. DOI: 10.1039/D1OB01500A

[195] Chemical synthesis of side-chain-hydroxylated vitamin D3 derivatives and their metabolism by CYP27B1

Ryota Sakamoto, Akiko Nagata, Haruki Ohshita, Yuka Mizumoto, Miho Iwaki, Kaori Yasuda, Toshiyuki Sakaki, Kazuo Nagasawa
ChemBioChem 2021, 22, 2896-2900. DOI: 10.1002/cbic.202100250

[194] Stabilization of telomeric G-quadruplex by ligand binding increases susceptibility to S1 nuclease

Ryo Ishikawa, Mizuho Yasuda, Shogo Sasaki, Yue Ma, Kazuo Nagasawa, Masayuki Tera
Chem. Commun. 2021, 57, 7236-7239. DOI: 10.1039/D1CC03294A

[193] Mechanistic Insights into Entropy-driven 1,2-Type Friedel-Crafts Reaction with Conformationally Flexible Guanidine-Bisthiourea Bifunctional Organocatalysts

Katsuhiro Nakano, Tatsuya Orihara, Masaki Kawaguchi, Keisuke Hosoya, Shogo Hirao, Ryosuke Tsutsumi, Masahiro Yamanaka, Minami Odagi, Kazuo Nagasawa
Tetrahedron 2021, 92, Article number:132281. DOI: 10.1016/j.tet.2021.132281

[192] Discovery of a VDR-Silent Vitamin D Derivatuve that Impairs SREBP in Vivo

Fumihiro Kawagoe, Aileen Mendoza, Yuki Hayata, Lisa Asano,Kenjiro Kotake, Sayuri Mototani, Satoshi Kawamura, Shigeyuki Kurosaki, Yusuke Akagi, Yasushi Takemoto, Kazuo Nagasawa, Hayato Nakagawa, Motonari Uesugi, Atsushi Kittaka
J. Med. Chem. 2021, 64, 5689-5709. DOI: 10.1021/acs.jmedchem.0c02179

[191] Differential diagnosis of vitamin D-related hypercalcemia using serum vitamin D metabolite profiling

Martin Kaufmann, Karl-Peter Schlingmann, Linor Berezin, Arnaud Molin, Jesse Sheftel, Melanie Vig, John C. Gallagher, Akiko Nagata, Shadi Sedghi Masoud, Ryota Sakamoto, Kazuo Nagasawa, Motonari Uesugi, Marie Laure Kottler, Martin Konrad, Glenville Jones
J. Bone Miner. Res. 2021, accepted. DOI: 10.1002/jbmr.4306

[190] Two new skeletal analogues of saxitoxin found in the scallop, Patinopecten yessoensis, as possible metabolites of paralytic shellfish toxins

Satoshi Numano, Yuta Kudo, Yuko Cho, Keiichi Konoki, Yoshimasa Koga, Kazuo Nagasawa, Mari Yotsu-Yamashita
Chemsphere 2021, 278, Article number:130224. DOI: 10.1016/j.chemosphere.2021.130224

[189] Enantioselective Total Synthesis of (+)-Stephadiamine through Bioinspired Aza-Benzilic Acid Type Rearrangement

Minami Odagi, Taisei Matoba, Keisuke Hosoya, Kazuo Nagasawa
J. Am. Chem. Soc. 2021, 143, 2699-2704. DOI: 10.1021/jacs.1c00047

[188] Selective alkylation of parallel G-quadruplex structure

Kazumitsu Onizuka, Erchissaran Ganbold, Yue Ma, Shogo Sasaki, Madoka E. Hazemi, Norihiro Sato, Kazuo Nagasawa, Fumi Nagatsugi
Org. Biomol. Chem. 2021, 19, 2891-2894. DOI: 10.1039/D0OB02365E

[187] Linear Consecutive Hexaoxazoles as G4 Ligands Inducing Chair-type Anti-parallel Topology of Telomeric G-Quadruplex

Shogo Sasaki, Yue Ma, Takumi Ishizuka, Hong-Liang Bao, Takatsugu Hirokawa, Yan Xu, Masayuki Tera, Kazuo Nagasawa
RSC Adv. 2020, 10, 43319-43323. DOI: 10.1039/D0RA09413G

[186] Enantioselective Epoxidation of 2,3-Disubstituted Naphthoquinones by Side-Chain-Truncated Guanidine-Urea Bifunctional Organocatalyst

Tatsuya Orihara, Masaki Kawaguchi, Keisuke Hosoya, Ryosuke Tsutsumi, Masahiro Yamanaka, Minami Odagi, Kazuo Nagasawa
J. Org. Chem. 2020, 85, 15232-15240. DOI: 10.1021/acs.joc.0c02084

[185] Target identification of a macrocyclic hexaoxazole G-quadruplex ligand using post-target-binding visualization

Mizuho Yasuda, Yue Ma, Sachiko Okabe, Yuki Wakabayashi, Dongdong Su, Young-Tae Chang, Hiroyuki Seimiya, Masayuki Tera, Kazuo Nagasawa
Chem. Commun. 2020, 56, 12905-12908. DOI:10.1039/D0CC04957C

[184] Synthesis of Hydrocarbazole Derivatives by Oxidative Dearomative Cyclization of Diarylamines using a Hypervalent Iodine Reagent

Keisuke Hosoya, Keita Iida, Minami Odagi, Kazuo Nagasawa
J. Org. Chem. 2020, 85, 11980-11988. DOI:10.1021/acs.joc.0c01760

[183] Isolation, Structure Determination, and Synthesis of Cyclic Tetraglutamic Acids from Box Jellyfish Species Alatina alata and Chironex yamaguchii

Justin Reinicke, Ryuju Kitatani, Shadi Sedghi Masoud, Kelly Kawabata Galbraith, Wesley Yoshida, Ayako Igarashi, Kazuo Nagasawa, Gideon Berger, Angel Yanagihara, Hiroshi Nagai, F. David Horgen
Molecules 2020, 25, Article number:883. DOI:10.3390/molecules25040883

[182] Synthesis of Spiroguanidine Derivatives by Dearomative Oxidative Cyclization using Hypervalent Iodine Reagent

Minami Odagi, Kazuma Okuda, Hayate Ishizuka, Kanna Adachi, Kazuo Nagasawa
Asian J. Org. Chem. 2020, 9, 218-221. DOI:10.1002/ajoc.201900726

[181] Synthesis of C12-keto saxitoxin derivatives with unusual inhibitory activity against voltage-gated sodium channels

Kanna Adachi, Tomoshi Yamada, Hayate Ishizuka, Mana Oki, Shunsuke Tsunogae, Noriko Shimada, Osamu Chiba,Tatsuya Orihara, Masafumi Hidaka, Takatsugu Hirokawa, Minami Odagi, Keiichi Konoki, Mari Yotsu-Yamashita, Kazuo Nagasawa
Chem. Eur. J. 2020, 26, 2025-2033. DOI:10.1002/chem.201904184

[180] Synthetic Chemical Probes That Dissect Vitamin D Activities

Akiko Nagata, Yusuke Akagi, Lisa Asano, Kenjiro Kotake, Fumihiro Kawagoe, Aileen Mendoza, Shadi Sedghi Masoud, Kosuke Usuda, Koji Yasui, Yasushi Takemoto, Atsushi Kittaka, Kazuo Nagasawa, Motonari Uesugi
ACS Chem. Biol. 2019, 14, 2851-2858. DOI:10.1021/acschembio.9b00718

[179] Introduction of Fluorine Atoms to Vitamin D3 Side-Chain and Synthesis of 24,24-Difluoro-25-hydroxyvitamin D3

Fumihiro Kawagoe, Sayuri Mototani, Kaori Yasuda, Kazuo Nagasawa, Motonari Uesugi, Toshiyuki Sakaki, Atsushi Kittaka
J. Steroid Biochem. Mol. Biol. 2019, 195, Article number:105477. DOI:10.1016/j.jsbmb.2019.105477

[178] Quantifying the impact of small molecule ligands on G-quadruplex stability against Bloom helicase

Parastoo Maleki, Golam Mustafa, Prabesh Gyawali, Jagat Budhathoki, Yue Ma, Kazuo Nagasawa, Hamza Balci
Nucl. Acids Res. 2019, 47, 10744-10753. DOI:10.1093/nar/gkz803

[177] Synthesis of Isoxazolidines by Intramolecular Hydroamination of N-Alkoxyamides in the Presence of a Visible-Light Photoredox Catalyst

Hayate Ishizuka, Kanna Adachi, Minami Odagi, Kazuo Nagasawa
Bull. Chem. Soc. Jpn. 2019, 92, 1447-1449. DOI:10.1246/bcsj.20190127

[176] Rif1 promotes association of G-quadruplex (G4) by its specific G4 binding and oligomerization activities

Hisao Masai, Rino Fukatsu, Naoko Kakusho, Yutaka Kanoh, Kenji Moriyama, Yue Ma, Keisuke Iida, Kazuo Nagasawa
Sci. Rep. 2019, 9, Article number: 8618. DOI: 10.1038/s41598-019-44736-9

[175] Impact of Small Molecules on Intermolecular G-quadruplex Formation

Prabesh Gyawali, Keshav GC, Yue Ma, Sanjaya Abeysirigunawardene, Kazuo Nagasawa, Hamza Balci
Molecules 2019, 24, Article number:1570. DOI:10.3390/molecules24081570

[174] Stereoselective Synthesis of Four Calcitriol Lactone Diastereomers at C23 and C25

Akiko Nagata, Yusuke Akagi, Shadi Sedghi Masoud, Masahiro Yamanaka, Atsushi Kittaka, Motonari Uesugi, Minami Odagi, Kazuo Nagasawa
J. Org. Chem. 2019, 84, 7630-7641. DOI:10.1021/acs.joc.9b00403

[173] Model studies for isolation of G-quadruplex-forming DNA sequences through a pull-down strategy with macrocyclic polyoxazole

Keisuke Iida, Yamato Tsushima, Yue Ma, Shadi Sedghi Masoud, Mai Sakuma, Tomomi Yokokawa, Wataru Yoshida, Kazunari Ikebukuro, Kazuo Nagasawa
Bioorg. Med. Chem. 2019, 27, 1742-1746. DOI:10.1016/j.bmc.2019.02.056

[172] Synthesis and Telomeric G-quadruplex-stabilizing Ability of Macrocyclic Hexaoxazoles bearing Three Side Chains

Yue Ma, Keisuke Iida, Shogo Sasaki, Takatsugu Hirokawa, Heddi Brahim, Anh Tu?n Phan, Kazuo Nagasawa
Molecules 2019, 24, Article number:263. DOI:10.3390/molecules24020263

[171] Synthesis of All Stereoisomers of RK460 and Evaluation of Activity and Selectivity as Abscisic Acid Receptor Antagonists

Yu Mikame, Kazuko Yoshida, Daisuke Hashizume, Go Hirai, Kazuo Nagasawa, Hiroyuki Osada, Mikiko Sodeoka
Chem. Eur. J. 2019, 25, 3496-3500. DOI:10.1002/chem.201806056

[170] Binding of a Telomestatin Derivative Changes Mechanical Anisotropy of Human Telomeric G-quadruplex

Sagun Jonchhe, Chiran Ghimire, Yunxi Cui, Shogo Sasaki, Soyoung Park, Keisuke Iida, Kazuo Nagasawa, Hiroshi Sugiyama, Hambin Mao
Angew. Chem., Int. Ed. 2019, 58, 877-881. DOI:10.1002/anie.201811046

[169] IDENTIFICATION OF TARGET PROTEIN FOR BATZELLADINES AS CD4

Jun Shimokawa, Kazuo Nagasawa
Heterocycles 2019, 99, 521-533 DOI:10.3987/COM-18-S(F)49

[168] Random formation of G-quadruplexes in the full-length human telomere overhangs leads to a kinetic folding pattern with targetable vacant G-tracts

Jibin Abraham Punnoose, Yue Ma, Mohammed Enamul Hoque, Yunxi Cui, Shogo Sasaki, Athene Huixin Guo, Kazuo Nagasawa, Hambin Mao
Biochemistry 2018, 57, 6946-6955 DOI:10.1021/acs.biochem.8b00957

[167] Molecular architecture of G-quadruplex structures generated on duplex Rif1 binding sequences

Hisao Masai, Naoko Kakusho, Rino Fukatsu, Yue Ma, Keisuke Iida, Yutaka Kanoh, Kazuo Nagasawa
J. Biol. Chem. 2018, 293, 17033-17049. DOI:10.1074/jbc.RA118.005240

[166] A Force Sensor that Converts Fluorescence Signal into Force Measurement Utilizing Short Looped DNA

Golam Mustafa, Cho-Ying Chuang, William A. Roy, Mohamed M. Farhath, Nilisha Pokhrel, Yue Ma, Kazuo Nagasawa, Edwin Antony, Matthew J. Comstock, Soumitra Basu, Hamza Balci
Biosens. Bioelectron. 2018, 121, 34-40. DOI:10.1016/j.bios.2018.08.073

[165] Analysis of interaction between telomeric i‐motif DNA and a cyclic tetraoxazole compound

Shadi Sedghi Masoud, Yudai Yamaoki, Yue Ma, Asrien Marchand, Fernaldo Richtia Winnerdy, Valérie Gabelica, Anh Tuan Phan, Masato Katahira, Kazuo Nagasawa
ChemBioChem 2018, 19, 2268-2272. DOI:10.1002/cbic.201800425

[164] Development of G-quadruplex ligands for selective induction of parallel-type topology

Yue Ma, Yamato Tsushima, Mai Sakuma, Shogo Sasaki, Keisuke Iida, Sachiko Okabe, Hiroyuki Seimiya, Takatsugu Hirokawa, Kazuo Nagasawa
Org. Biomol. Chem. 2018, 16, 7375-7382. DOI:10.1039/C8OB01702F

[163] Esterification of PQQ enhances blood-brain barrier permeability and inhibitory activity against amyloidogenic protein fibril formation

Kaori Tsukakoshi, Wataru Yoshida, Masaki Kobayashi, Natsuki Kobayashi, Jihoon Kim, Toshisuke Kaku, Toshitsugu Iguchi, Kazuo Nagasawa, Ryutaro Asano, Kazunori Ikebukuro, Koji Sode
ACS Chem. Neursci. 2018, 9, 2898-2903. DOI:10.1021/acschemneuro.8b00355

[162] Asymmetric Epoxidation of 1,4-Naphthoquinones Catalyzed by Guanidine–Urea Bifunctional Organocatalyst

Masaki Kawaguchi, Katsuhiro Nakano, Keisuke Hosoya, Tatsuya Orihara, Masahiro Yamanaka , Minami Odagi, Kazuo Nagasawa
Org. Lett. 2018, 20, 2811-2815. DOI:10.1021/acs.orglett.8b00641

[161] Synthesis of a Quaternary N,N'-Aminal-Containing A-E Ring System of Palau'amine via Enamide-type Overman Rearrangement Reaction

Takuya Imaoka, Makoto Iwata and Kazuo Nagasawa
Eur. J. Org. Chem. 2018, 2018, 2572-2578. DOI:10.1002/ejoc.201800086

[160] A synthesis of 2,6,7-trisubstituted prenylated indole

Motoki Shiozawa, Keisuke Iida, Minami Odagi, Masahiro Yamanaka, Kazuo Nagasawa
J. Org. Chem. 2018, 83, 7276-7280. DOI:10.1021/acs.joc.7b03273

[159] Identification of G-quadruplex clusters by high-throughput sequencing of whole-genome amplified products with a G-quadruplex ligand

Wataru Yoshida, Hiroki Saikyo, Kazuhiko Nakabayashi, Hitomi Yoshioka, Daniyah Habiballah Bay, Keisuke Iida, Tomoko Kawai, Kenichiro Hata, Kazunori Ikebukuro, Kazuo Nagasawa, Isao Karube
Sci. Rep. 2018, 8, Article number:3116. DOI:10.1038/s41598-018-21514-7

[158] Total Synthesis of (+)-Gracilamine Based on Oxidative Phenolic Coupling Reaction and Determination of its Absolute Configuration

Minami Odagi, Yoshiharu Yamamoto, Kazuo Nagasawa
Angew. Chem., Int. Ed. 2018, 57, 2229-2232. DOI:10.1002/anie.201708575

[157] Targeting STUB1-tissue factor axis normalizes hyperthrombotic uremic phenotype without increasing bleeding risk

Moshe Shashar, Mostafa E. Belghasem, Shinobu Matsuura. Faisal Alousi, Keshab Rijal, Vijaya B. Kolachalama, Mercedes Balcells, Minami Odagi, Kazuo Nagasawa, Joel M. Henderson, Amitabh Gautam, Jean Francis, Kumaran Kolandaivelu, David H. Sherr, Katya Ravid, Vipul C. Chitalia
Sci. Transl. Med. 2017, 9, eaam8475. DOI:10.1126/scitranslmed.aam8475

[156] FAN1 acts in concert with ubiquitylated PCNA to alleviate replication stress and preserve genome integrity

Antonio Porro, Matteo Berti, Julia Pizzolato, Anja Saxer, Yue Ma, Kazuo Nagasawa, Alessandro A. Sartori, Josef Jiricny
Nat. Commun. 2017, 8, Article number:1073. DOI:10.1038/s41467-017-01074-6

[155] Identification of G-quadruplex structures that possess transcriptional regulating functions in the Dele and Cdc6 CpG islands

Daniyah H. Bay, Annika Busch, Fred Lisdat, Keisuke Iida, Kazunori Ikebukuro, Kazuo Nagasawa, Isao Karube, Wataru Yoshida
BMC Mol. Biol. 2017, 18, 17. DOI:10.1186/s12867-017-0094-z

[154] Guanidinium Hydroiodide/Cumene Hydroperoxide-Mediated Intermolecular Oxidative Coupling Reaction of β-Ketoamides with Oxindoles

Takanari Kato, Koji Yasui, Minami Odagi, Kazuo Nagasawa
Adv. Synth. Catal. 2017, 359, 2881-2889. DOI:10.1002/adsc.201700266

[153] Structure-dependent binding of hnRNP A1 to telomere RNA

Xiao Liu, Takumi Ishizuka, Hong-Liang Bao, Kei Wada, Yuuma Takada, Keisuke Iida, Kazuo Nagasawa, Danzhou Yang, and Yan Xu
J. Am. Chem. Soc. 2017, 139, 7533-7539. DOI:10.1021/jacs.7b01599

[152] Adaptive and Specific Recognition of Telomeric G-quadruplexes via Polyvalency Induced Unstacking of Binding Units

Jibin Abraham Punnoose, Yue Ma, Yuanyuan Li, Mai Sakuma, Shankar Mandal, Kazuo Nagasawa, Hanbin Mao
J. Am. Chem. Soc. 2017, 139, 7476-7484. DOI:10.1021/jacs.7b00607

[151] Targeting glioma stem cells in vivo by a G-quadruplex-stabilizing synthetic macrocyclic hexaoxazole

Takahiro Nakamura, Sachiko Okabe, Haruka Yoshida, Keisuke Iida, Yue Ma, Shogo Sasaki, Takao Yamori, Kazuo Shin-ya, Ichiro Nakano, Kazuo Nagasawa and Hiroyuki Seimiya
Sci. Rep. 2017, 7, Article number:3605. DOI:10.1038/s41598-017-03785-8

[150] Total Synthesis of Rishirilide B Based on Organocatalytic Oxidative Kinetic Resolution: Revision of Absolute Configuration of (+)-Rishirilide B

Minami Odagi, Kota Furukori, Kan Takayama, Keiichi Noguchi, Kazuo Nagasawa
Angew. Chem., Int. Ed. 2017, 56, 6609-6612. DOI:10.1002/anie.201701431
Highlighted by Synfacts

[149] Synthesis and identification of key biosynthetic intermediates for formation of the tricyclic skeleton of saxitoxin

Shigeki Tsuchiya, Yuko Cho, Renpei Yoshioka, Keiichi Konoki, Kazuo Nagasawa, Yasukatsu Oshima, and Mari Yotsu-Yamashita
Angew. Chem., Int. Ed. 2017, 56 , 5327-5331. DOI:10.1002/anie.201612461

[148] A G-quadruplex structure at the 5′ end of the H19 coding region regulates H19 transcription

Mitsuko Fukuhara, Yue Ma, Kazuo Nagasawa, Fumiko Toyoshima
Sci. Rep. 2017, 7, Article number: 45815. DOI:10.1038/srep45815

[147] Oxidative kinetic resolution of cis-fused tricyclic 1-tetralone derivatives by guanidine-bisurea bifunctional organocatalyst

Minami Odagi, Keisuke Hosoya, Yoshiharu Yamamoto, Kazuo Nagasawa
Synlett 2017, 28, 1305-1309. DOI:10.1055/s-0036-1588151

[146] Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP

Lisa Asano, Mizuki Watanabe, Yuta Ryoden, Kousuke Usuda, Takuya Yamaguchi, Bilon Khambu, Megumi Takashima, Shin-ichi Sato, Juro Sakai, Kazuo Nagasawa, Motonari Uesugi
Cell Chem. Biol. 2017, 24, 207-217. DOI:10.1016/j.chembiol.2016.12.017
Highlighted by 朝日新聞DIGITAL, WORLD PHARMAN NEWS, Kyoto Univ., iCeWS, EurekAlert! and ASIA RESEARCH NEWS

[145] Total Synthesis of Pyrrole-Imidazole Alkaloid (+)-Cylindradine B

Makoto Iwata, Yuko Kamijoh, Eri Yamamoto, Masahiro Yamanaka, and Kazuo Nagasawa
Org. Lett. 2017, 19, 420-423. DOI:10.1021/acs.orglett.6b03722

[144] A Single Molecule Study of a Fluorescently Labeled Telomestatin Derivative and G-Quadruplex Interactions

Parastoo Maleki, Yue Ma, Keisuke Iida, Kazuo Nagasawa, Hamza Balci
Nucl. Acids Res. 2016, 45, 288-295. DOI:10.1093/nar/gkw1090

[143] Structural regulation by a G-quadruplex ligand increases binding abilities of G-quadruplex-forming aptamers

Kaori Tsukakoshi, Yuri Ikuta, Koichi Abe, Wataru Yoshida, Keisuke Iida, Yue Ma, Kazuo Nagasawa, Koji Sode and Kazunori Ikebukuro
Chem. Commun. 2016, 52, 12646-12649. DOI:10.1039/c6cc07552e

[142] Regulation mechanism of the vitamin D receptor by vitamin D lactam derivatives

Lisa Asano, Tsuyoshi Waku, Rumi Abe, Naoyuki Kuwabara, Ichiaki Ito, Junn Yanagisawa, Kazuo Nagasawa, Toshiyuki Shimizu
FEBS Lett. 2016, 590, 3270-3279. DOI:10.1002/1873-3468.12348

[141] Total Synthesis of 11-Saxitoxinethanoic Acid and Evaluation of its Inhibitory Activity on Voltage-gated Sodium Channels

Chao Wang, Mana Oki, Toru Nishikawa, Daisuke Harada, Mari Yotsu-Yamashita and Kazuo Nagasawa
Angew. Chem., Int. Ed. 2016, 55, 11600-11603. DOI:10.1002/anie.201604155

[140] Synthesis of 1α- and 1β-amino-25-hydroxyvitamin D3

Yusuke Akagi, Kosuke Usuda, Tomoe Tanami, Koji Yasui, Lisa Asano, Motonari Uesugi, Kazuo Nagasawa
Asian. J. Org. Chem. 2016, 10, 1247-1252. DOI:10.1002/ajoc.201600300

[139] Guanidinium Iodide/Urea Hydrogen Peroxide-Catalyzed Azidation of β-Dicarbonyl Compounds with Trimethylsilyl Azide

Koji Yasui, Kohei Kojima, Takanari Kato, Minami Odagi, Masaru Kato, and Kazuo Nagasawa
Tetrahedron 2016, 72, 5350-5354. DOI:10.1016/j.tet.2016.07.015

[138] Detection of DNA methylation of G-quadruplex and i-motif-forming sequences by measuring the initial elongation efficiency of PCR

Wataru Yoshida, Hitomi Yoshioka, Daniyah Habiballah Bay, Keisuke Iida, Kazunori Ikebukuro, Kazuo Nagasawa, Isao Karube
Anal. Chem. 2016, 88, 7101-7107. DOI:10.1021/acs.analchem.6b00982

[137] Synthesis of 24,24-difluoro-1,3-cis-25-dihydroxy-19-norvitamin D3 derivatives and evaluation of their vitamin D receptor-binding affinity

Tanima Biswas, Yusuke Akagi, Kosuke Usuda, Koji Yasui, Isao Shimizu, Mayumi Okamoto, Motonari Uesugi, Seijiro Hosokawa, Kazuo Nagasawa
Biol. Pharm. bull. 2016, 39, 1387-1391. DOI:10.1248/bpb.b16-00316

[136] Synthesis of diasteromers of 1,3-cis-25-dihydroxy-19-norvitamin D3

Kosuke Usuda, Tanima Biswas, Takuya Yamaguchi, Yusuke Akagi, Koji Yasui, Motonari Uesugi, Isao Shimizu, Seijiro Hosokawa, Kazuo Nagasawa
Chem. Pharm. bull. 2016, 64, 1190-1195. DOI:10.1248/cpb.c16-00311

[135] Design and synthesis of unsymmetric macrocyclic hexaoxazole compounds with ability to induce distinct G-quadruplex topologies in telomeric DNA

Mai Sakuma, Yue Ma, Yamato Tsushima, Keisuke Iida, Takatsugu Hirokawa, Kazuo Nagasawa
Org. Biomol. Chem. 2016, 14, 5109-5116. DOI:10.1039/C6OB00437G

[134] Asymmetric α-amination of β-keto esters using guanidine-bisurea bifunctional organocatalyst

Minami Odagi, Yoshiharu Yamamoto, Kazuo Nagasawa
Beilstein J. Org. Chem. 2016, 12, 198-203. DOI:10.3762/bjoc.12.22

[133] Biosynthetic route towards saxitoxin and shunt pathway

Shigeki Tsuchiya, Yuko Cho, Keiichi Konoki, Kazuo Nagasawa, Yasukatsu Oshima, Mari Yotsu-Yamashita
Sci. Rep. 2016, 6, Article number: 20340. DOI:10.1038/srep20340

[132] Synthesis of (+)-trans-dihydrolycoridine using orgacocatalytic enantioselective Friedel-Crafts reaction

Masaru Kato, Koji Yasui, Masahiro Yamanaka, Kazuo Nagasawa
Asian J. Org. Chem. 2016, 5, 380-388. DOI:10.1002/ajoc.201500469

[131] Design, Synthesis and Evaluation of an L-Dopa-Derived Macrocyclic Hexaoxazole (6OTD) as a G-Quadruplex-Selective Ligand

Takahiro Nakamura, Yue Ma, Keisuke Iida, Terumi Ohtake, Hiroyuki Seimiya, Kazuo Nagasawa
Heterocycles, 2016, 92, 305-315. DOI:10.3987/COM-15-13383

[130] Entropy-driven 1,2-Type Friedel-Crafts Reaction of Phenols with N-Boc Aldimines

Masaru Kato, Shogo Hirao, Katsuhiro Nakano, Makoto Sato, Masahiro Yamanaka, Yoshihiro Sohtome, Kazuo Nagasawa
Chem. Eur. J. 2015, 21, 18606-18612. DOI:10.1002/chem.201503280

[129] Rif1 binds to G-quadruplex and suppresses replication over a long distance

Yutaka Kanoh, Seiji Matsumoto, Rino Fukatsu, Naoko Kakusho, Nobuaki Kono, Claire Renard-Guilet, Koji Masuda, Keisuke Iida, Kazuo Nagasawa, Katsuhiko Shirahige, Hisao Masai
Nat. Struct. Mol. Biol. 2015, 22, 889-897. DOI:10.1038/nsmb.3102

[128] Development of Guanidine-Bisurea Bifunctional Organocatalyst with a Chiral Pyrrolidine Moiety and Application to α-Hydroxylation of Tetralone-Derived β-Keto Esters

Minami Odagi, Kan Takayama, Makoto Sato, Masahiro Yamanaka, Kazuo Nagasawa
Molecules 2015, 20, 12590-12598. DOI:10.3390/molecules200712590

[127] Time-resolved crystal structures of the reaction intyermediate of nitrile hydrase reveal a role for the cystein-sulfenic acid ligand as a catalyst nucleophile

Yasuaki Yamanaka, Yuki Kato, Koichi Hashimoto, Keisuke Iida, Kazuo Nagasawa, Hiroshi Nakayama, Naoshi Dohmae, Keiichi Noguchi, Takumi Noguchi, Masafumi Yohda, Masafumi Odaka
Angew. Chem., Int. Ed. 2015, 54, 10763-10767. DOI:10.1002/anie.201502731

[126] Synthesis of a tricyclic bisguanidine compound structurally related to saxitoxin and its identification in paralytic shellfish toxins-producing microorganisms

Shigeki Tsuchiya, Yuko Cho, Keiichi Konoki, Kazuo Nagasawa, Yasukatsu Oshima, Mari Yotsu-Yamashita
Chem. Eur. J. 2015, 21, 7835-7840. DOI:10.1002/chem.201500064

[125] Development of Guanidine-Bisurea Bifunctinaol Organocatalyst Bearing Chirality at the Inner and Outer Sides of Urea Groups, and Application to Enantioselective α-Hydroxylation of Pyranoindolizine Intermediate for Camptothecin Synthesis

Minami Odagi, Tatsuya Watanabe, Kazuo Nagasawa
Symmetry 2015, 7, 43-52. DOI:10.3390/sym7010043

[124] Origin of stereocontorol in guanidine-bisurea bifunctional organocatalyst that promotes α-hydroxylation of tetralone-derived β-ketoesters: Asymmetric synthesis of β- or γ-substituted tetralone derivatives via organocatalytic oxidative kinetic resolution

Minami Odagi, Kota Furukori, Yoshiharu Yamamoto, Makoto Sato, Keisuke Iida, Masahiro Yamanaka, Kazuo Nagasawa
J. Am. Chem. Soc. 2015, 137, 1909-1915. DOI:10.1021/ja511149y
Highlighted by ACS Select Virtual Issue "Organocatalyst"

[123] Guanidium Iodine-Catalyzed Oxidative α-Nitroalkylation of β-Ketoamides

Koji Yasui, Takanari Kato, Kohei Kojima, Kazuo Nagasawa
Chem. Commun. 2015, 51, 2290-2293. DOI:10.1039/C4CC08581G

[122] Conformational changes and cation ejection upon ligand binding to human telomeric DNA G-quadruplexes

Adrien Marchand, Anton Granzhan, Keisuke Iida, Yamato Tsushima, Yue Ma, Kazuo Nagasawa, Marie-Paule Teulade-Fichou, Vale'rie Gabelica
J. Am. Chem. Soc. 2015, 137, 750-756. DOI:10.1021/ja5099403

[121] 2-(4-Hydroxy-3-methoxyphenyl)-benzothiazole suppresses tumor progression and metastatic potential of breast cancer cells by inducing ubiquitin ligase CHIP

Hiromi Hiyoshi, Natsuka Goto, Mai Tsuchiya, Keisuke Iida, Yuka Nakajima, Naoya Hirata, Yasunari Kanda, Kazuo Nagasawa, Junn Yanagisawa
Sci. Rep. 2014, 4, Article number:7095. DOI:10.1038/srep07095

[120] Direct Quantification of Loop Interaction and π-π Stacking for G-quadruplex Stability at the Sub-molecular Level

Chiran Ghimire, Soyoung Park, Keisuke Iida, Philip Yangyuoru, Haruka Otomo, Zhongbo Yu, Kazuo Nagasawa, Hiroshi Sugiyama, and Hanbin Mao
J. Am. Chem. Soc. 2014, 136, 15537-15544. DOI:10.1021/ja503585h

[119] Synthesis of an advance model of zetekitoxin AB focusing on N-acylisoxazolidine amide structure corresponding to C13~C17

Toru Nishikawa, Chao Wang, Takafumi Akimoto, Hiroyuki Koshino, Kazuo Nagasawa
Asian j. Org. Chem. 2014, 3, 1308-1311. DOI:10.1002/ajoc.201402206

[118] Synthesis of Macrocyclic Penta- and Tetraoxazoles as G-Quadruplex Ligands

Shadi Sedghi Masoud, Tsushima Yamato, Keisuke Iida, Kazuo Nagasawa
Heterocycles 2014, 90, 866-873. DOI:10.3987/COM-14-S(K)90

[117] Synthesis of 19-nor-vitamin D A-ring synthons via ring-closing olefin metathesis (RCM) reaction

Yu Nagai, Tomoe Tanami, Junko Abe, Hazuki Nagai, Toru Hamamizu, Kaichiro Kominato, Keisuke Iida, Kazuo Nagasawa
Asian J. Org. Chem. 2014, 3, 994-999. DOI:10.1002/ajoc.201402109
Selected as a Very Important Paper (VIP)

[116] Total synthesis of (+)-Cylindradine A

Makoto Iwata, Kyohei Kanoh, Takuya Imaoka, Kazuo Nagasawa
Chem. Commun. 2014, 50, 6991-6994. DOI:10.1039/C4CC00137K

[115] Development of Novel Guanidine-Bisurea Bifunctional Organocatalysts and Their Application to Asynnetric α-Hydroxylation of Tetralone-Derived β-Keto Esters

Minami Odagi, Kan Takayama, Kota Furukori, Tatsuya Watanabe, Kazuo Nagasawa
Aust. J. Chem. 2014, 67, 1017-1020. DOI:10.1071/CH14144

[114] Synthesis and identification of proposed biosynthetic intermediates of saxitoxin in the cyanobacterium Anabaena circinalis (TA04) and the binoflagellate Alexandrium tamarense (Axat-2)

Shigeki Tsuchiya, Yuko Cho, Keiichi Konoki, Kazuo Nagasawa, Yasukatsu Oshima, Mari Yotsu-Yamashita
Org. Biomol. Chem. 2014, 12, 3016-3020. DOI:10.1039/C4OB00071D

[113] Asymmetric Michael Reaction of Nitroolefins with beta-Dicarbonyl Compounds Catalysed by 1,3-Diamine-Tethered Guanidine-Thiourea Bifunctional Organocatalysts

Natsuko Horitsugi, Kohei Kojima, Koji Yasui, Yoshihiro Sohtome, Kazuo Nagasawa
Asian J. Org. Chem. 2014, 3, 445-448. DOI:10.1002/ajoc.2011402002R1

[112] Identification of a Novel Compound That Suppresses Breast Cancer Invasiveness by Inhibiting Transfoming Growth Factor-beta Signaling via Estrogen Receptor α

Natsuka Goto, Hiromi Hiyoshi, Ichiaki Ito, Keisuke Iida, Yuka Nakajima, Kazuo Nagasawa, Junn Yanagisawa
J. Cancer 2014, 5, 336-343. DOI:10.7150/jca.7202

[111] Asymmetric α-Hydroxylation of Lactone with Vinylogous Pyridone using Guanidine-Urea Bifunctional Organocatalyst: Catalystic Enantioselective Synthesis of a Key Intermediate for (20S)-Camptothecin Analogues

Tatusya Watanabe, Minami Odagi, Kota Furukori, Kazuo Nagasawa
Chem. Eur. J. 2014, 20, 591-597. DOI:10.1002/chem.201303633

[110] A nonclassical vitamin D receptor pathway suppresses renal fibrosis

Ichiaki Ito, Tsuyoshi Waku, Masato Aoki, Rumi Abe, Yu Nagai, Tatsuya Watanabe, Yuka Nakajima, Ichiro Ohkido, Keitaro Yokoyama, Hiroyuki Miyachi, Toshiyuki Shimizu, Akiko Murayama, Hiroyuki Kishimoto, Kazuo Nagasawa, Junn Yanagisawa
J. Clin. Invest. 2013, 123, 4579-4594. DOI:10.1172/JCI67804

[109] Fluorescent ligand-mediated screening of G-quadruplex structure using a DNA microarray

Kesuke Iida, Takahiro Nakamura, Wataru Yoshida, Masayuki Tera, Kazuhiko Nakabayashi, Kenichiro Hata, Kazunori Ikebukuro, Kazuo Nagasawa
Angew. Chem., Int. Ed. 2013, 52, 12052-12055. DOI:10.1002/anie.201305366
Highlighted by Nikkan BizLine and TUAT press release

[108] Asymmetric α-hydroxylation of Tetralone Derived β-Ketoesters using Guanidine-Urea Bifunctional Organocatalyst in the Presence of Cumene Hydroperoxide

Minami Odagi, Kota Furugori, Tatsuya Watanabe, Kazuo Nagasawa
Chem. Eur. J. 2013, 19, 16740-16745. DOI:10.1002/chem.201303006

[107] Synthesis of Macrocyclic Dimer of Cyclic Hexaoxazole and Examination of Its Interaction with Telomeric Oligonucleotide

Keisuke Iida, Gen Tsubouchi, Takahiro Nakamura, Kazuo Nagasawa
Heterocycles 2014, 88, 1287-1298. DOI:10.3987/COM-13-S(S)97

[106] Solution Structure of an Intramolecular (3 + 1) Human Telomeric G-Quadruplex Bound to a Telomestatin Derivative

Wan Jun Chung, Brahim Heddi, Masayuki Tera, Keisuke Iida, Kazuo Nagasawa, Anh Tu?n Phan
J. Am. Chem. Soc. 2013, 135, 13495-13501. DOI:10.1021/ja405843r
Highlighted by Faculty of 1000

[105] Synthesis of saxitoxin derivatives bearing guanidine and urea groups at C13 and evaluation of their inhibitory activity on voltage-gated sodium channel

Takafumi Akimoto, Asako Masuda, Mari Yotsu-Yamashita, Takatsugu Hirokawa, Kazuo Nagasawa
Org. Biomol. Chem. 2013, 11, 6642-6649. DOI:10.1039/C3OB41398
Highlighted by Pubadvanced

[104] A tandem Friedel-Crafts based method for the construction of tricyclic pyrroquinoline skeleton and its application to the synthesis of ammosamide B

Yohei Takayama, Tatsuya Yamada, Shinya Tatekabe, Kazuo Nagasawa
Chem. Commun. 2013, 49, 6519-6521. DOI:10.1039/C3CC42463D

[103] Evaluation of the Interaction between Long Telomeric DNA and Macrocyclic Hexaoxazole (6OTD) Dimer of a G-quadruplex Ligand

Keisuke Iida, Satoki Majima, Takahiro Nakamura, Hiroyuki Seimiya, Kazuo Nagasawa
Molecules 2013, 18, 4328-4341. DOI:10.3390/molecules18044328

[102] Sequential Enantiodivergent Organocatalysis: Reversibility in Enantioswitching Controlled by a Conformationally Flexible Guanidine/Bisthiourea Organocatalyst

Yoshihiro Sohtome, Takahisa Yamaguchi, Shinji Tanaka, Kazuo Nagasawa
Org. Biomol. Chem. 2013, 11, 2780-2786. DOI:10.1039/C3OB27479A

[101] Interaction of long telomeric DNAs with macrocyclic hexaoxazole as a G-quadruplex ligands

Keisuke Iida, Gen Tsubouchi, Takahiro Nakamura, Satoki Majima, Hiroyuki Seimiya, Kazuo Nagasawa
Med. Chem. Commun. 2013, 4, 260-264. DOI:10.1039/C2MD20234D

[100] Intramolecular 1,3-Dipolar Cycloaddition-Mediated Stereoselective Synthesis of Disubstituted Cyclopentane, a Simple Model for Cyclopentane Ring System of Polycyclic Oroidine Alkaloids

Yusuke Fukahori, Yohei Takayama, Takuya Imaoka, Osamu Iwamoto, Kazuo Nagasawa
Chem. Asian J. 2013, 8, 244-250. DOI:10.1002/asia.201200820

[99] Synthesis of vitamin D3 derivatives with nitrogen-linked substituents at A-ring C-2 and evaluation of their vitamin D receptor-mediated transcriptional activity

Junko Abe, Yu Nagai, Rui Higashikuni, Keisuke Iida, Takatsugu Hirokawa, Hazuki Nagai, Kaichiro Kominato, Toshio Tsuchida, Michiko Hirata, Masaki Inada, Chisato Miyaura, Kazuo Nagasawa
Org. Biomol. Chem. 2012, 10, 7826-7836. DOI:10.1039/C2OB26017D

[98] A Caged Ligand for a Telomeric G-Quadruplex

Takahiro Nakamura, Keisuke Iida, Masayuki Tera, Kazuo Shin-ya, Hiroyuki Seimiya, Kazuo Nagasawa
ChemBioChem 2012, 13, 774-777. DOI:10.1002/cbic.201200013

[97] Agrocybynes A-E from the culture broth of Agrocybe praecox

Keiji Fushimi, Kota Anzai, Shinji Tokuyama, Yoshikazu Kiriiwa, Noriyuki Matsumoto, Atsushi Sekiya, Daisuke Hashizume, Kazuo Nagasawa, Hirofumi Hirai, Hirokazu Kawagishi
Tetrahedron 2012, 68, 1262-1265. DOI:10.1016/j.tet.2011.11.049

[96] Design and Synthesis of G-Quadruplex Ligands Bearing Macrocyclic Hexaoxazoles with Four-Way Side Chains

Keisuke Iida, Satoki Majima, Terumi Ootake, Masayuki Tera, Kazuo Shin-ya, Kazuo Nagasawa
Heterocycles 2012, 84, 401-404. DOI:10.3987/COM-11-S(P)88

[95] Enantioselective epoxidation of α,β-unsaturated ketones catalyzed by stapled helical l-Leu-based peptides

Yosuke Demizu, Nanako Yamagata, Saori Nagoya, Yukiko Sato, Mitsunobu Doi, Masakazu Tanaka, Kazuo Nagasawa, Haruhiro Okuda, Masaaki Kurihara
Tetrahedron 2011, 67, 6155-6165. DOI:10.1016/j.tet.2011.06.075

[94] Synthesis of Skeletal Analogues of Saxitoxin Derivatives and Evaluation of Their Inhibitory Activity on Sodium Ion Channels NaV1.4 and NaV1.5

Ryoko Shinohara, Takafumi Akimoto, Osamu Iwamoto, Takatsugu Hirokawa, Mari Yotsu-Yamashita, Kaoru Yamaoka, Kazuo Nagasawa
Chem. Eur. J. 2011, 17, 12144-12151. DOI:10.1002/chem.201101058

[93] Development of a novel biosensing system based on the structural change of a polymerized guanine-quadruplex DNA nanostructure

Yo Morita, Wataru Yoshida, Nasa Savory, Sung Woong Han, Masayuki Tera, Kazuo Nagasawa, Chikashi Nakamura, Koji Sode, Kazunori Ikebukuro
Biosens. Bioelectron. 2011, 26, 4837-4841. DOI:10.1016/j.bios.2011.05.050

[92] Organocatalytic Asymmetric Synthesis of N,N-Bis(dihydrofuranyl)hydroxyamines: A Cascade Reaction Involving Friedel-Crafts Alkylation, Internal Redox Reaction, and Umpolung

Yoshihiro Sohtome, Yoshihiro Yamaguchi, Bongki Shin, Kazuo Nagasawa
Chem. Lett. 2011, 40, 843-845. DOI:10.1246/cl.2011.843

[91] Enantioselective Phospha-Michael Reaction of Diphenyl Phosphonate with Nitroolefins Utilizing Conformationally Flexible Guanidinium/Bisthiourea Organocatalyst: Assembly-State Tunability in Asymmetric Organocatalysis

Yoshihiro Sohtome, Natsuko Horitsugi, Rika Takagi, Kazuo Nagasawa
Adv. Synth. Cat. 2011, 353, 2631-2636. DOI:10.1002/adsc.201100219

[90] Osteoclast-forming suppressing compounds, gargalols A, B and C, from the edible mushroom Grifola gargal

Jing Wua, Jae-Hoon Choi, Miyuki Yoshida, Hirofumi Hirai, Etsuko Harada, Kikuko Masuda, Tomoyuki Koyama, Kazunaga Yazawa, Keiichi Noguchi, Kazuo Nagasawa, Hirokazu Kawagishi
Tetrahedron 2011, 67, 6576-6581. DOI:10.1016/j.tet.2011.05.091

[89] Analysis of unbinding force between telomestatin derivatives and human telomeric G-quadruplex by atomic force microscopy

Yosuke Amemiya, Yui Furunaga, Keisuke Iida, Masayuki Tera, Kazuo Nagasawa, Kazunori Ikebukuro, Chikashi Nakamura
Chem. Commun. 2011, 47, 7485-7487. DOI:10.1039/C0CC05781A

[88] Linking Conformational Flexibility and Kinetics: Catalytic 1,4-Type Friedel–Crafts Reactions of Phenols Utilizing 1,3-Diamine-Tethered Guanidine/Bisthiourea Organocatalysts

Yoshihiro Sohtome, Bongki Shin, Natsuko Horitsugi, Keiichi Noguchi, Kazuo Nagasawa
Chem. Asian. J. 2011, 6, 2463-2470. DOI:10.1002/asia.201100363

[87] Design of a stabilized short helical peptide and its application to catalytic enantioselective epoxidation of (E)-chalcone

Nanako Yamagata, Yosuke Demizua, Yukiko Sato, Mitsunobu Doi, Masakazu Tanakad, Kazuo Nagasawa, Haruhiro Okuda, Masaaki Kurihara
Tetrahedron Lett. 2011, 52, 798-801. DOI:10.1016/j.tetlet.2010.12.030

[86] (S)-Stereoisomer of telomestatin as a potent G-quadruplex binder and telomerase inhibitor

Takayuki Doi, Kazuaki Shibata, Masahito Yoshida, Motoki Takagi, Masayuki Tera, Kazuo Nagasawa, Kazuo Shin-ya, Takashi Takahashi
Org. Biomol. Chem. 2011, 9, 387-393. DOI:10.1039/C0OB00513D

[85] Design and Synthesis of Telomestatin Derivatives Containing Methyl Oxazole and Their G-Quadruplex Stabilizing Activities

Satoki Majima, Masayuki Tera, Keisuke Iida, Kazuo Shin-ya, Kazuo Nagasawa
Heterocycles 2011, 82, 1345-1357. DOI:10.3987/COM-10-S(E)85

[84] A Novel Glucosylation Reaction on Anthocyanins Catalyzed by Acyl-Glucose–Dependent Glucosyltransferase in the Petals of Carnation and Delphinium

Yuki Matsuba, Nobuyuki Sasaki, Masayuki Tera, Masachika Okamura, Yutaka Abe, Emi Okamoto, Haruka Nakamura, Hisakage Funabashi, Makoto Takatsu, Mikako Saito, Hideaki Matsuoka Kazuo Nagasawa, Yoshihiro Ozeki
Plant Cell 2010, 22, 3374-3389. DOI:10.?1105/?tpc.?110.?077487

[83] Solvent-Dependent Enantiodivergent Mannich-Type Reaction: Utilizing a Conformationally Flexible Guanidine/Bisthiourea Organocatalyst

Yoshihiro Sohtome,. Shinji Tanaka, Keisuke Takada, Takahisa Yamaguchi, Kazuo Nagasawa
Angew. Chem., Int. Ed. 2010, 49, 9254-9257. DOI:10.1002/anie.201005109

[82] Entropy-Controlled Catalytic Asymmetric 1,4-Type Friedel–Crafts Reaction of Phenols Using Conformationally Flexible Guanidine/Bisthiourea Organocatalyst

Yoshihiro Sohtome, Bongki Shin, Natsuko Horitsugi, Rika Takagi, Keiichi Noguchi, Kazuo Nagasawa
Angew. Chem., Int. Ed. 2010, 49, 7299-7303. DOI:10.1002/anie.201003172

[81] Total Synthesis of (+)-Dibromophakellin and (+)-Dibromophakellstatin

Takuya Imaoka, Takafumi Akimoto, Osamu Iwamoto, Kazuo Nagasawa
Chem. Asian. J. 2010, 5, 1810-1816. DOI:10.1002/asia.201000213

[80] Visualization of G-quadruplexes by using a BODIPY-labeled macrocyclic heptaoxazole.

Masayuki Tera, Keisuke Iida, Kazunori Ikebukuro, Hiroyuki Seimiya, Kazuo Shin-ya, Kazuo Nagasawa
Org. Biomol. Chem. 2010, 8, 2749-2755. DOI:10.1039/C002117B

[79] Total Synthesis of (+)-Decarbamoylsaxitoxin and (+)-Gonyautoxin 3

Osamu Iwamoto, Kazuo Nagaswa
Org. Lett. 2010, 12, 2150-2153. DOI:10.1021/ol1006696

[78] Synthesis of Macrocyclic Hexaoxazole (6OTD) Dimers, Containing Guanidine and Amine Functionalized Side Chains, and an Evaluation of Their Telomeric G4 Stabilizing Properties

Keisuke Iida, Masayuki Tera, Takatsugu Hirokawa, Kazuo Shin-ya, Kazuo Nagasawa
J. Nucleic Acids 2010, Article number:217627. DOI:10.4061/2010/217627

[77] Disabling c-Myc in Childhood Medulloblastoma and Atypical Teratoid/Rhabdoid Tumor Cells by the Potent G-Quadruplex Interactive Agent S2T1-6OTD

Tarek Shalaby, André O. von Bueren, Marie-Louise Hürlimann, Giulio Fiaschetti, Deborah Castelletti, Tera Masayuki, Kazuo Nagasawa, Alexandre Arcaro, Ilian Jelesarov, Kazuo Shin-ya, Michael Grotzer
Mol. Cancer Ther. 2010, 9, 167-179. DOI:10.1158/1535-7163.MCT-09-0586

[76] Synthesis of (+)-Batzelladine K

Miyuki Sekine, Yumi Iijima, Osamu Iwamoto, Kazuo Nagasawa
Heterocycles 2010, 80, 395-408. DOI:10.3987/COM-09-S(S)36

[37] Advances in the Administration of Vitamin D Analogues to Support Bone Health and Treat Chronic Diseases

Yoshiaki Kanemoto, Miho Iwaki, Takahiro Sawada, Koki Nojiri, Tomohiro Kurokawa, Rino Tsutsumi, Kazuo Nagasaw, Shigeaki Kato
J. Bone Metab. 2023, 30, 219-229. DOI:10.11005/jbm.2023.30.3.219

[36] Chiral Hypoiodite Salt Catalysts for Enantioselective Oxidative Transformations

Minami Odagi, Kazuo Nagasawa
ChemCatChem 2023, 15, e202300820. DOI:10.1002/cctc.202300820

[35] Exploring Guanidinium Organocatalysts for Hypoiodite-Mediated Reactions

Minami Odagi, Kazuo Nagasawa
Chem. Rec. 2023, 23, e202300030. DOI:10.1002/tcr.202300030

[34] Total Synthesis of Fused Polycyclic Alkaloids Based on Oxidative Phenolic Coupling Reaction and Aza-Michael Reaction

Minami Odagi, Kazuo Nagasawa
Synlett 2023, 34, 1087-1097. DOI: 10.1055/a-2007-9342

[33] Chemical targeting of G-quadruplexes in telomeres and beyond for molecular cancer therapeutics

Hiroyuki Seimiya, Kazuo Nagasawa, Kazuo Shin-ya
J. Antibiot. 2021, 74, 617-628. DOI:10.1038/s41429-021-00454-x

[32] Recent Advances in Synthetic Strategies for The C4a,C9a-Fused Tetracyclic Hydrocarbazole Core Structure of Minfiensine and Related Akuammiline Alkaloids

Keisuke Hosoya, Keita Iida, Minami Odagi, Kazuo Nagasawa
Heterocycles 2021, 103, 110-128. DOI:10.3987/REV-20-SR(K)3

[31] Topologies of G-quadruplex: Biological functions and regulation by ligands

Yue Ma, Keisuke Iida, Kazuo Nagasawa
Biochem. Biophys. Res. Commun. 2020, 531, 3-17. DOI:10.1016/j.bbrc.2019.12.103

[30] Synthetic approaches to zetekitoxin AB, a potent voltage-gated sodium channel inhibitor

Kanna Adachi, Hayate Ishizuka, Minami Odagi, Kazuo Nagasawa
Marine Drugs 2020, 18, Article number:24. DOI:10.3390/md18010024

[29] Recent Advances in Natural Products Synthesis Using Bifunctional Organocatalysts bearing a Hydrogen-bonding Donor Moiety

Minami Odagi, Kazuo Nagasawa
Asian J. Org. Chem. 2019, 8, 1766-1774. DOI:10.1002/ajoc.201900459

[28] i-Motif-binding ligands and their effects on the structure and biological functions of i-motif

Shadi Sedghi Masoud, Kazuo Nagasawa
Chem. Pharm. Bull. 2018, 66, 1091-1103. DOI:10.1248/cpb.c18-00720

[27] Guanidine Organocatalysis for Enantioselective Carbon-Heteroatom Bond-forming Reactions

Keisuke Hosoya, Minami Odagi, Kazuo Nagasawa
Tetrahedron Lett. 2018, 8, 687-696. DOI:10.1016/j.tetlet.2017.12.058

[26] Synthetic studies of (23S,25R)-1,α,25-dihydroxyvitamin D3 26,23-lactone (calcitriol lactone) and its derivatives

Yusuke Akagi, Akiko Nagata, Minami Odagi, Kazuo Nagasawa
J. Steroid Biochem. Mol. Biol. 2018, 177, 240-246. DOI:10.1016/j.jsbmb.2017.07.017

[25] Total Synthesis of (+)-Linoxepin

Minami Odagi, Kota Furukori, Yoshiharu Yamamoto, Kazuo Nagasawa
Heterocycles 2017, 95, 116-126. DOI:10.3987/REV-16-SR(S)3

[24] A-Ring Synthons of 19-Nor Type Vitamin D Derivatives

Yusuke Akagi, Koji Yasui, Kazuo Nagasawa
J. Steroid. Biochem. Mol. Biol. 2017, 173 , 64-68. DOI:10.1016/j.jsbmb.2016.07.003

[23] 有機分子触媒を用いる不斉反応の開発と天然物合成への応用

小田木陽、長澤和夫
月刊「化学工業」 2017, 68, **–**. DOI:No record

[22] Synthetic Studies of Oroidin-derived Pyrrole-imidazole Alkaloids

Makoto Iwata, Yuko Kamijoh, Kazuo Nagasawa
J. Synth. Org. Chem., Jpn. 2015, 73, 1092-1098. DOI:10.5059/yukigoseikyokaishi.73.1092

[21] Sequential stereodivergent organocatalysis and programmed organocascade

Yoshihiro Sohtome, Kazuo Nagasawa
Org. Biomol. Chem. 2014, 12, 1681-1685. DOI:10.1039/C3OB42310G

[20] 触媒的不斉酸化反応にも大活躍！–進化する環境にやさしい超原子価ヨウ素試薬

安井浩二、小田木陽、長澤和夫
月刊「化学」 2014, 69, 70–71. DOI:No record

[19] G-Quadruplexes as a Potential Therapeutic Target for Embryonal Tumors

Tarek Shalaby, Giulio Fiaschetti, Kazuo Nagasawa, Kazuo Shin-ya, Martin Baumgartner, Michael Grotzer
Molecules 2013, 18, 12500-12537. DOI:10.3390/molecules181012500

[18] Macrocyclic Polyoxazoles as G-Quadruplex Ligands

Keisuke Iida, Kazuo Nagasawa
Chem. Rec. 2013, 13, 539-548. DOI:10.1002/tcr.201300015

[17] Synthetic Approaches to Tetracyclic Pyrrole Imidazole Marine Alkaloids

Takuya Imaoka, Makoto Iwata, Takafumi Akimoto, Kazuo Nagasawa
Nat. Prod. Commun. 2013, 8, 961-964. DOI:no recored

[16] Dynamic asymmetric organocatalysis: cooperative effects of weak interactions and conformational flexibility in asymmetric organocatalysts

Yoshihiro Sohtome, Kazuo Nagasawa
Chem. Commum. 2012, 48, 7777-7789. DOI:10.1039/c2cc31846f

[15] Synthesis of saxitoxins

Osamu Iwamoto, Takafumi Akimoto, Kazuo Nagasawa
Pure Appl. Chem. 2012, 84, 1445-1453. DOI:10.1351/PAC-CON-11-09-10

[14] The Design of Chiral Double Hydrogen Bonding Networks and Their Applications to Catalytic Asymmetric Carbon-Carbon and Carbon-Oxygen Bond-Forming Reactions

Yoshihiro Sohtome, Kazuo Nagasawa
Synlett 2010, 1-22. DOI:10.1055/s-0029-1218542

[13] Synthetic Studies on Cyclic Guanidine Natural Products for the Elucidation of Their Controlling Mechanism of Protein-protein Interaction

Kazuo Nagasawa, Jun Shimokawa
J. Synth. Org. Chem., Jpn. 2006, 64, 539-547. DOI:10.5059/yukigoseikyokaishi.64.539

[12] Thalidomide as a multitarget drug and its application as a template for drug design

Yuichi Hashimoto, Aya Tanatani, Kazuo Nagasawa, Hiroyuki Miyachi
Drags Future 2004, 29, 383-391. DOI:10.1358/dof.2004.029.04.792298

[11] Synthesis of Marine Guanidine Alkaloids and Their Application Chemical/Biological Tools

Kazuo Nagasawa, Yuichi Hashimoto
Chem. Rec. 2003, 3, 201-2011. DOI:10.1002/tcr.10064

[10] Phase-Transfer Catalysts

長澤和夫
ファルマシア 2003, 39, 670. DOI:No record

[9] Total synthesis of marine cyclic guanidine compounds and development of novel guanidine type asymmetric organocatalysts

Kazuo Nagasawa
Yakugaku Zasshi 2003, 123, 387-398. DOI:No record

[8] サリドマイドの構造展開と活性拡張

長澤和夫、橋本祐一
細胞工学 2003, 22, 152-155. DOI:No record

[7] 古くて新しい高原子価ヨウ素試薬：IBX

長澤和夫
ファルマシア 2002, 38, 1096. DOI:No record

[6] ***

[5] Total Synthesis of Pinnatoxin A

Kazuo Nagasawa
J. Synth. Org. Chem., Jpn. 2000, 58, 877-886. DOI:10.5059/yukigoseikyokaishi.58.877

[4] ボランによるC-H結合活性化

長澤和夫
ファルマシア 2000, 36, 320. DOI:No record

[3] ***

[2] ***

[1] Palladium-Catalyzed Hydrogenolysis of Allylic Compounds with Formic Acid : Its Application to Organic Synthesis

Isao Shimizu, Masato Oshima, Kazuo Nagasawa, Jiro Tsuji, Tadakatsu Mandai
J. Synth. Org. Chem., Jpn. 1991, 49, 526-540. DOI:10.5059/yukigoseikyokaishi.49.526

[15] Modern Natural Product Synthesis

Oxidative Phenolic Coupling Reaction/Aza-Michael Reaction Strategy for the Synthesis of Complex Polycyclic Alkaloids
Minami Odagi, Kazuo Nagasawa
Springer(2024),
Masahisa Nakada, Keiji Tanino, Kazuo Nagasawa, Satoshi Yokoshima Ed., pp.205-228.

[14] Handbook of Chemical Biology of Nucleic Acids

Macrocyclic G-Quadruplex Ligands of Telomestatin Analogs
Yue Ma, Keisuke Iida, Kazuo Nagasawa
Springer (2022), Naoki Sugimoto Ed., pp. **-**.

[13] Marine Natural Products

Synthesis of Paralytic Shellfish Toxins: Saxitoxins
Hayate Ishizuka, Kazuo Nagasawa
Springer (2021), Hiromasa Kiyota Ed., pp. 131-152

[12] 核酸科学ハンドブック

核酸四重鎖結合分子
飯田圭介、馬悦、長澤和夫
講談社サイエンティフィック (2021), 杉本直己編, pp. 380-384.

[11] 有機分子触媒の開発と工業利用

グアニジン触媒を用いた不斉分子変換反応
細谷圭介、長澤和夫
シーエムシー出版 (2018), 秋山隆彦編, pp. 126-139.

[10] Designed Molecular Space in Material Science and Catalysis

Design of the Chiral Enviroment for Asymmetric Acid-Base Catalysis
Yoshihiro Sohtome, Kazuo Nagasawa, Mikiko Sodeoka
Springer (2018), Seiji Shirakawa Ed., pp. 91-121.

[9] Guanidines as Reagents and Catalysts I

Conformationally Flexible Guanidine–(Thio)Urea Bifunctional Organocatalysts
Kazuo Nagasawa, Minami Odagi, Masaru Kato
Springer (2017), Philipp Selig Ed., pp. 157-178.